SOX9 and lung cancer: In accordance with these findings, the depletion of endogenous KEAP1 by short hairpin RNA (shRNA)‐mediated knockdown or CRISPR‐mediated knockout in multiple liver and lung cancer cell lines led to a marked increase in the abundance of SOX9 protein (Figure 2E and Figure S2E, Supporting Information), but not its mRNA levels (Figure S2F, Supporting Information).