In accordance with these findings, the depletion of endogenous KEAP1 by short hairpin RNA (shRNA)‐mediated knockdown or CRISPR‐mediated knockout in multiple liver and lung cancer cell lines led to a marked increase in the abundance of SOX9 protein (Figure 2E and Figure S2E, Supporting Information), but not its mRNA levels (Figure S2F, Supporting Information). Here, KEAP1 is linked to lung cancer.