To establish a mechanistic link between SOX9 and the KEAP1 mutations specifically associated with lung carcinoma, we investigated a set of KEAP1 missense mutations identified in this cancer type.[34] Toward this end, we constructed a series of plasmids harboring KEAP1 mutants with point‐mutations, of which, 12 mutations are located in the Kelch domain. This evidence concerns the gene KEAP1 and lung carcinoma.