Typically, sepsis is accompanied by a cytokine storm,[4] a deadly uncontrollable systemic inflammatory response resulting from the burst of vast amounts of pro‐inflammatory cytokines by immune effector cells.[28] Therefore, we evaluated the effects of DNase‐I pMNSs on NF‐κB activation and cytokine secretion from neutrophils. This evidence concerns the gene NFKB1 and Sepsis.