The 2018 Tokyo Guidelines provide diagnostic criteria for acute cholecystitis: local signs of inflammation, such as Murphy's sign or right-upper quadrant tenderness, systemic signs of inflammation like fever, and elevated C-reactive protein (CRP) or elevated white blood cell count (WBC) [4]. A suspected diagnosis includes one local sign of inflammation and one systemic sign of inflammation, while a definitive diagnosis contains imaging characteristic of acute cholecystitis (Table 2). The gene discussed is CRP; the disease is Cholecystitis, Acute.