PLOD1 and hypogonadism: Rhodin et al. found in their study on female patients on opioids that the mean estradiol value was 208 pmol/L vs. 510 pmol/L (P < 0.05), DHEAS levels were 40.6 vs. 65.3 mg/l, the LH peak was 17.6 IE/L vs. 38.3 IE/L (P < 0.01), and the baseline FSH was 25.7 IE/L vs. 60.7 IE/L (P < 0.05) compared to the controls [19].The data supports that opioid-induced hypogonadism is through the suppression of the HPG axis along with ovarian and adrenal androgen production explaining both central and peripheral effects.