PLOD1 and erectile dysfunction: Daniell demonstrated that among men on oral opioids, 89% showed reduced levels of free testosterone, dihydrotestosterone, estradiol, LH, and FSH (P < 0.0001), and 87% reported erectile dysfunction and reduced libido [23]. Daniell also proved that in opioid-consuming postmenopausal women, independent of BMI and age, average values of LH and FSH were 70% to 73% lower than the control group (P < 0.001), with median values of 4.1 and 32.5 mIU/ml for LH and 7.1 and 71.0 mIU/ml for FSH [24].