Rhodin et al. found in their study on female patients on opioids that the mean estradiol value was 208 pmol/L vs. 510 pmol/L (P < 0.05), DHEAS levels were 40.6 vs. 65.3 mg/l, the LH peak was 17.6 IE/L vs. 38.3 IE/L (P < 0.01), and the baseline FSH was 25.7 IE/L vs. 60.7 IE/L (P < 0.05) compared to the controls [19].The data supports that opioid-induced hypogonadism is through the suppression of the HPG axis along with ovarian and adrenal androgen production explaining both central and peripheral effects. This evidence concerns the gene BRD2 and hypogonadism.