The study concluded that the decreased production of interferon-gamma could reflect the anergic state seen in the peripheral blood T lymphocytes of patients with sarcoidosis, and also concluded that the ability of TLR-9 to increase the production of IL-23 could indicate that functional defects in the immune pathway of TLR-9 could increase the susceptibility to sarcoidosis [14]. This evidence concerns the gene IFNG and sarcoidosis.