Wang et al. (2019a) and Wang et al. (2019b) reported that the lncRNA MALAT1 regulated PD-L1 by sponging miR-195 in diffuse large B cell lymphoma, affecting PD-L1’s proliferation, apoptosis, migration, and immune escape capacities. Notably, our study confirmed that ZFPM2-AS1 knockdown decreased PD-L1 expression in the presence of IFN-γ, suggesting that ZFPM2-AS1 may be a potential target during PD-L1 immunotherapy. Here, ZFPM2 is linked to diffuse large B-cell lymphoma.