RUNX3 and gastric cancer: A significant number of genes with different biological functions havecurrently been identified in which the promoter regions or the first exon aremethylated in gastric cancer [30].Meanwhile, methylation of the regulatory regions of the bves, irx1,runx3, cacna2d3, lrrc3b, and sfrp2 genes presented inTable 3 isassociated with at least three subtypes of gastriccancer [17].