In pancreatic cancer cells, the transcription factor ZEB1 plays a key role inthe regulation of EMT and the metastatic process by suppressing the E-cadherinexpression via the recruitment of HDAC1 and HDAC2 deacetylases to the promoterregion of the CDH1 gene[63, 64]. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.