ABCD1 and X-linked adrenoleukodystrophy: The Abcd1– mutant mouse exhibits late-onset axonal degeneration of the spinal cord corticospinal tracts and microglial and astroglial activation, compatible with chronic low-level stimulation of the innate immune response, and constitutes a good model for ALD (Pujol et al., 2002; Ruiz et al., 2015).