LDLR and familial hyperaldosteronism: Chemical chaperones or pharmacological chaperones (PCs) have been identified as a promising new strategy to re-instate ER-Golgi-cell surface transport of ER-retained mutant proteins including class II LDLR mutants that retain their original biological function to some extent (a detailed review is performed in the coming section “Therapeutic Potential of Pharmacological Chaperones (PCs) and Proteostasis Regulators (PRs) in the Disease Management of FH”).