Our data showed that old VIP-eGFP mice spent much less time in the open arms (p < 0.001, t-test; Figures 1I,J, center) with less entries into open arms (p < 0.001, t-test; Figures 1I,J, right), indicative of increased anxiety although decreased locomotion could also account for these changes. The gene discussed is VIP; the disease is Anxiety.