ERBB2 and cancer: Multiple molecules involved in glycolysis have been reported to be associated to HER-2 signaling pathway in cancer cells, such as lactate dehydrogenase A (LDHA), a key enzyme in the glycolytic pathway, the level of which is facilitated by overexpression of HER-2 which further enhances the utilization of glucose and decreases the consumption of oxygen in breast cancer cells 25.