Collectively, the present study used a holistic approach to analyze transcription profiles of PTTG family members as well as to predict their prognostic statuses in different breast cancer subtypes, in an attempt to provide useful insights in prospective research of cancer associations with the PTTG gene family; therefore, they can possibly serve as distinctive biomarkers and potential prognosticators in breast cancer. The gene discussed is PTTG1; the disease is cancer.