Additionally, simultaneous neprilysin inhibition and AT1‐receptor blockade reportedly control glucose and lipid metabolism in obese patients, including natriuretic peptides, bradykinin, endothelin‐1, and glucagon‐like peptide 1 36, thus elucidating the effect of LCZ696 on lipolysis and mitigating hyperlipidemia in STZ-treated rats. This evidence concerns the gene MME and hyperlipidemia.