We utilized this rat model that displays hyperglycemia-induced oxidative stress, inflammation and hepatic fibrosis to evaluate the impact of combined angiotensin receptor blocker (valsartan) and neprilysin inhibitor (sacubitril) on STZ-induced oxidative stress, inflammation, and hepatic fibrosis in comparison to valsartan alone. The gene discussed is MME; the disease is Hepatic fibrosis.