The anti-angiogenic effect of gallic acid in ovarian cancer is due to the downregulation of the Phosphatase and tensin homologue deleted on chromosome 10/Protein kinase B/Hypoxia-inducible factor-1alpha (PTEN/AKT/HIF-1α) pathway and inhibition of vascular endothelial growth factor (VEGF) expression 8. This evidence concerns the gene HIF1A and ovarian carcinoma.