The expression of HNF1B was upregulated in bladder urothelial carcinoma (BLCA), cholangiocarcinoma (CHOL), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), stomach adenocarcinoma (STAD), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC), while the expression of HNF1B was downregulated in colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), and lung squamous cell carcinoma (LUSC). The gene discussed is HNF1B; the disease is colon adenocarcinoma.