In the leukemias generated by Mir142−/− + IDH2R140Q cells, the majority of the lineage negative, c-Kit+ progenitor cells in the bone marrow had a GMP-like phenotype, and the proportion of GMPs was significantly increased in the Mir142−/− + IDH2R140Q double mutants compared to the single IDH2R140Q mutants (48% compared to 21% of GFP+ BM progenitor cells) (Fig. 5f), with a particularly large increase in the frequency of GMPs within the spleen (Fig. 5g). Here, KIT is linked to leukemia.