This investigation was founded on the following facts: the role of ZMYM3 as one of the top three genes involved in the progression of late-onset AD, exceptional length of the STR in human and human-specificity of the STR complex formula in which this STR is located, a link between this STR and instances of cognition deficit (a property that is severely compromised in NCD), its predominant expression in the human brain, and proximity to the + 1 TSS. Here, ZMYM3 is linked to Cognitive impairment.