Regarding IL-8 secretion, although we observed the decrease of α3 integrin levels after 24 h of incubation with P. brasiliensis yeasts, the upmodulation of α3 integrin levels in the first 5 h of A549 cell infection seems to be important to promote this cytokine secretion, since after α3 integrin silencing, we observed a reduction of IL-8 levels9. Here, CXCL8 is linked to infection.