The observed DC activation and IFN-γ+ T-cell responses in mice treated with gels containing the increased dose of Dox-iRGD and CpG correlated with significantly reduced tumor growth compared to untreated mice (Fig. 4f and Supplementary Fig. 10a, b), with median survival increasing by 50% to 45 days (Fig. 4g and Supplementary Fig. 10c). The gene discussed is IFNG; the disease is neoplasm.