VPS35 and Parkinson disease: Notably, the MINs from the three rare genetic PD patients all presented smaller diameters for the subnetworks that are composed of nodes larger than a certain number (≥34, 16, 27, 34, and 14 for SNCA mutation, SNCA triplication, RHOT1 mutation, and VPS35 mutation with or without oxidative stress, respectively, Fig. 4a), whereas the efficiency was always higher than that of age- and gender-matched healthy controls (Fig. 4b).