We analyzed the MINs in the samples from patients with heterozygous point mutations, namely in the SNCA gene (PARK1) encoding alpha-synuclein14, in the PD-associated gene RHOT1 encoding a mitochondrial outer membrane GTPase15,16 (MIRO1), and in the VPS35 gene (PARK17) encoding the vacuolar protein sorting-associated protein 35 (VPS35)17–19. This evidence concerns the gene SNCA and Parkinson disease.