Strikingly, 13 of the 22 targets (59%) were highly interconnected with known breast cancer genes: CST3, S100A11, MAPK11, STK11, CDT1, HOMER3, TRIM28, RPL28, NCAPH2, SF3A2, SLC25A10, SEZ6L2, and MEIS3 (Fig. 4C). The gene discussed is HOMER3; the disease is breast carcinoma.