We have previously shown that male B6N mice deficient in a protein-coding exon of Gnaz, the gene encoding for Gαz, are fully protected from hyperglycemia and glucose intolerance, even after up to 26 to 30 weeks of consuming a 45 kcal% fat diet (HFD) starting at 11 weeks of age (8). Here, GNAZ is linked to Glucose intolerance.