MTMR14 and obesity due to melanocortin 4 receptor deficiency: Similarly, apabetalone differentially reduced gene expression of the phagocytic macrophage receptor CD68 [41], of the IL-10 receptor subunit IL10RB implicated in pro- and anti-inflammatory homeostasis [42], and of MTMR14 encoding a phosphoinositide phosphatase involved in metabolic dysregulation in obesity [43].