PSEN1 and Alzheimer disease: To validate our novel Mouse AD panel, a time-course analysis was performed to correlate human AMP-AD co-expression modules with the 5xFAD mouse model carrying a transgenic insertion with five familial mutations in APP and PSEN1. The 5xFAD strain is a commonly used model of neurodegenerative disease for which neuropathology, histological as well as behavioral data are readily available (Fig. 4a).