This proportion is increased when we focused on patients without any mutation in the genes traditionally involved in lung carcinogenesis such as EGFR, KRAS, BRAF, HER2, ALK, ROS1 (34.8 and 52.2% when we applied the cut-off of r = 1 or of the median value, respectively), supporting the hypothesis that ROR1 could constitute a potential tumor driver in a significant number of lung AC. This evidence concerns the gene ROS1 and neoplasm.