While currently B7-H6 has been well established as an activating ligand for NKp30, initially a different molecule, BAG-6, a BCL-2 associated anti-apoptotic protein associated with tumor cells, was considered to be the only activating ligand for NKp30 [26, 27]; in 2009 Brandt et al. demonstrated that B7-H6, another surface molecule on tumor cells, could bind and activate NKp30 [10]. The gene discussed is BAG6; the disease is neoplasm.