APC and colorectal carcinoma: In previous gene focused studies, several somatic mutations in known CRC driver genes have been identified (namely, APC, KRAS, TP53 and BRAF) [2] and GWAS (Genome-Wide Association Studies) continue to elucidate CRC pathogenetic mechanisms by identification of associated genes and suggest collection of genes of common function possibly important in targeted mechanisms associated with the development of CRC.