This collective evidence suggests that potassium channels may play an important role in CRC risk, development and metastasis and that Kv2.1 in particular, through modified expression attributed to KCNB1 mutations (rs3331, rs1051295 and rs11468831) [18] is a notable candidate of the potential role of potassium channel proteins in CRC. The gene discussed is KCNB1; the disease is colorectal carcinoma.