Previous studies have determined that TDP-43, FUS, SFPQ, hnRNPA1 and hnRNPK undergo changes in cellular localisation in response to various stressors, but this type of investigation has not been conducted in the cell types most relevant to neurodegenerative disease, and precise molecular mechanisms remain incompletely resolved [11,12,13,14,15,16]. The gene discussed is TARDBP; the disease is neurodegenerative disease.