Among the upregulated genes in Madrid samples, ten showed isoforms in which overexpression was different depending on the year (Table 3); the number of isoforms from the six genes overexpressed in both years (HSP, glycoside hydrolase, Leucin rich repeat, EF hand family, pollen allergy, and coifilin), only in 2017 (Pectinesterase and serpin) and only in 2018 (lipid transfer protein and thaumatin) are indicated in the table. Here, HSP90B2P is linked to seasonal allergic rhinitis.