A negative correlation analysis of CDH1 expression in relation to the proteins that activate integrins through RGD sequences, which potently induce endothelial retraction, revealed DEL-1 (developmental endothelial locus-1, also called EDIL3), PODXL (podocalyxin-like protein 1) and THBS1 (thrombospondin 1) in melanoma cells as p38/MK2 targets that mediate melanoma invasiveness [46]. The gene discussed is THBS1; the disease is melanoma.