PPARA and oral lichen planus: This lack of (or insufficient) mobilization of an endogenous PEA response to dampen the inflammation in OLP opens up the possibility that exogenous PEA may be a potentially useful treatment strategy for this disorder, given its anti-inflammatory properties (not least its ability to downmodulate mast cells [16] and to reduce levels of inflammatory cytokines secondary to its effects upon PPAR-α [12,13]; for review, see [44]) and given that current treatment strategies (primarily topical corticosteroid treatment) are suboptimal.