These data were further confirmed by miRCancerdb analysis that showed weak-moderate positive correlations between the two down-regulated miRNAs and three of the four down-regulated genes (DLG2, CPEB4, PAIP2B), and weak negative correlations between the two down-regulated miRNAs and three of the ten significantly up-regulated genes in oral cancer (HOXC11, EIF2AK2, CTSC) (Table 2). The gene discussed is EIF2AK2; the disease is lip and oral cavity carcinoma.