TP53 and lip and oral cavity carcinoma: In the case of oral cancer, such risk factors were associated with the mutations and changes of expression genes involved in the EGFR epidermal growth factor pathway (including TGF-β, fibroblastic growth factor-BP (FGF-BP) and MMK6) and genes, including CDKN2A, TP53, SYNE1, NOTCH1, and PIK3CA notoriously involved in different tumors [16,17].