The research performed on (51) patients divided into extrinsic (42) and intrinsic (9) groups unveiled stronger activation of all inflammatory pathways based on the Th2 lymphocyte axe, especially including particular Th17 and Th22 lymphocyte cytokine pathways in the intrinsic type of AD with normal serum level of IgE and negative family allergy history. The gene discussed is IGHE; the disease is Allergy.