NLRP3 and gout: NLRP3 component of inflammasome becomes an important component of the inflammatory system involved both in the antibacterial and fungal defense, but also in the pathogeny of chronic diseases that have inflammatory pathogeny as T2D, gout, atherosclerosis, autoimmune diseases, and Alzheimer disease and its specific inhibition may provide the opportunity for targeted therapy in CMS, too [6,7,8].