Gut microbiota disturbances like reduced Gram-positive bacteria from Firmicutes spp (Clostridia, Bacilia, etc.,) decreased in butyrate-producing bacteria (Roseburia, Butyrivibrio) and increased Gram-negative spp (E. Coli, Bacteroides) specific for T2D and CMS are responsible for diminishing insulin sensitivity, epithelial dysfunction and increase epithelial permeability, increased capacity for harvesting energy and stimulating lipogenesis and NLRP3 inflammasome activation. This evidence concerns the gene NLRP3 and type 2 diabetes mellitus.