However, findings on novel specific markers in the development of lymphatic endothelial cells (LECs) during embryogenesis, such as the vascular endothelial growth factor (VEGF-C), lymphatic vascular endothelial cell hyaluronin receptor 1 (LYVE-1), podoplanin, and homeobox transcription factor 1 (PROX-1), have led to their extensive investigation and an understanding of their mechanism of action in lymphangiogenesis, in normal and pathological conditions, such as cancer. The gene discussed is VEGFC; the disease is cancer.