In contrast, VEGF-D was found to regulate the enzyme that breaks down prostaglandin in endothelial cells, namely 15-hydroxyprostaglandin dehydrogenase (15-PGDH), resulting in the prolonged exposure of LECs in collecting lymphatics to prostaglandins and enlargement of the lymphatic vessels, hence allowing the dissemination of tumor cells [100,101]. The gene discussed is HPGD; the disease is neoplasm.