The greatest differences relating to elevated Ng levels in CSF were observed in the AD+ group (n = 238) compared to MCI- (n = 241) (RoM: 1.59, 95% CI (1.38 to 1.85), z = 6.24, p < 0.001) (Figure 2A) (Supplementary Figure S16, Supplementary Table S3 (6.A)). Here, NRGN is linked to Alzheimer disease.