Marginally smaller differences in Ng levels were observed between the AD+ (n = 238) and CTRL- (n = 187) groups (1.54, 95% CI (1.32 to 1.80), z = 5.53, p < 0.001) (Figure 2B) (Supplementary Figure S17, Supplementary Table S3 (6.B)) as well as between patients in the MCI+ (n = 430) and CTRL- (n = 187) groups (1.45, 95% CI (1.17 to 1.81), z = 3.33, p < 0.001) (Figure 2C) (Supplementary Figure S18, Supplementary Table S3 (6.C)). Here, NRGN is linked to Alzheimer disease.