Recently, Petiti et al. described a chronic-phase CML patient with a unique atypical transcript (BCR e13(-53nt)/ins 119nt ABL 1b/ABL ex2) where the designing of a patient-specific ddPCR assay allowed to quantify the MRD from diagnosis to follow up [54]. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.