In conclusion, this study proposes a mechanistic model for how AMPKαl regulates autophagy induction, thereby causing cancer progression as depicted in Figure 7F. AMPKαl interacts with TRAF6 and BECN1 to form a tri-molecular complex, TRAF6-AMPKαl-BECN1 (Figure 7F, left). This evidence concerns the gene BECN1 and cancer.