TLR4 and cancer: Importantly, levels of TLR1, TLR10, TLR3, TLR4, TLR5, TLR6, TLR7, and TLR8 were significantly up-regulated in group 1 cancer tissues expected for patient 7, but markedly down-regulated in group 2 tumor tissues (Figure 5D, group 1 versus group 2).