For example, expression of several actin-related factors were mis-regulated upon MEMO1 knockdown in colorectal cancer (CRC) cell lines, including down-regulation of Actin Related Protein 2 (ARP2)/Neural Wiskott Aldrich Syndrome Protein (N-WASP) and up-regulation of WASP Family Verprolin Homologous Protein (WAVE-1), relative to control cells [37]. Here, ACTR2 is linked to colorectal carcinoma.