MEMO1 and Intellectual disability: While the number of ASD probands with MEMO1 variants, identified to date, is relatively small, copy number variation (CNV) databases such as DECIPHER [79], reveals additional individuals with deletions or duplications of regions encompassing MEMO1. Several of these affected individuals are reported to have a range of cognitive and neuronal impairments, including autism, intellectual disability, global developmental delay and seizures.