While numerous mechanisms likely exist—whether direct or indirect—studies in colorectal cancer cell lines did reveal that one transcription factor complex, Aryl Hydrocarbon Receptor (AhR)/AhR Nuclear Translocator (ARNT), directly bound the MEMO1 promoter, driving MEMO1 expression in response to HER2 signaling [37]. The gene discussed is ERBB2; the disease is colorectal cancer.