NK cell dysfunction is associated with significant phenotypic alterations, including a decreased expression of the natural cytotoxicity receptors (NCRs) in solid tumors and hematological malignancies, and the downregulation of the activating receptors DNAX Accessory Molecule-1 (DNAM-1) and Natural Killer Group 2D (NKG2D) [4,5,6,7]. The gene discussed is CD226; the disease is hematologic disorder.