EIF4EBP1 and cancer: In fact, the results indicate that the cancer cells are not the most sensitive to sonoporation in terms of uptake of cell-impermeable molecule, reduction in viability or intracellular signalling response (phosphorylation of p38, ERK1/2, ribosomal protein S6 and 4E-BP1), further suggesting that cells in the tumour microenvironment may be relevant for sonoporation efficacy.