Interestingly, it has been demonstrated that TFEB activities are highly modulated by a Ca2+-enriched microenvironment that is created following lysosomal Ca2+ release mediated by TRPML1 channels [77] and that TFEB itself modulates the lysosomal Ca2+ buffering capacity [78], thereby suggesting a primary role of lysosomal Ca2+ in TFEB-associated cancers. This evidence concerns the gene MCOLN1 and cancer.