CCL2 and metabolic dysfunction-associated steatohepatitis: Xiao et al. assessed the effect of LBP in rats with non-alcoholic steatohepatitis and found that LBP has able to attenuate pro-inflammatory cytokines such as TNFα, IL-1β, cyclooxygenase 2(COX2) and monocyte chemoattractant protein-1 (MCP1) as well as profibrotic factors such as TGFβ-1, α-SMA and Smad 2/4 expression significantly compared to untreated rats with NASH [15].