Because of its crucial role in the regulation of the host immune response, TIM-3 has previously been correlated with the pathogenesis of many clinical diseases, such as liver diseases, hyperreactive airway diseases such as asthma, and several autoimmune diseases such as rheumatoid arthritis or type 1 diabetes [17,18,19,20,21,22,23]. This evidence concerns the gene HAVCR2 and rheumatoid arthritis.