Because of its crucial role in the regulation of the host immune response, TIM-3 has previously been correlated with the pathogenesis of many clinical diseases, such as liver diseases, hyperreactive airway diseases such as asthma, and several autoimmune diseases such as rheumatoid arthritis or type 1 diabetes [17,18,19,20,21,22,23]. Here, HAVCR2 is linked to autoimmune disease.