TLR4 and malignant colon neoplasm: Simultaneous activation of toll-like receptor (TLR)-4 and 9 responses of the same autophagy in macrophages and the CT26 colon cancer cell can occur through the use of GO [395], in addition to the injection of this material stimulates the infiltration of immune cells into the tumor bed, curbing the augmentation of colon cancer in mice [398].