It was observed GAB2 knock out mice are resistant to CML-like myeloproliferative neoplasms induced by BCR-ABL [9], a constitutively active fusion tyrosine kinases, capable of transforming hematopoietic stem cells, which is generated in CML by a translocation between chromosome 9 and 22; t(9;22)(q34;q11). Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.