In vivo deletion of the miR-221/222 cluster in the liver suppressed TIMP3, a secreted protein that binds to the extracellular matrix and blocks activation of several cell membrane metalloproteases, including a disintegrin and metalloproteinase 17 (ADAM17) and TNF-α converting enzyme; suppression of TIMP3 by deleting the miR-221/222 cluster inhibited hepatic fibrosis [70,71]. The gene discussed is TIMP3; the disease is Hepatic fibrosis.