Notably, several oncogenic miRNAs, such as miR-200a-3p, miR-183, miR-141, and miR-193a-3p, can promote 5-FU resistance; miR-200a-3p enhanced HCC 5-FU-resistance by suppressing the expression of dual-specificity phosphatase 6 (DUSP6) [225,226,227]. This evidence concerns the gene DUSP6 and hepatocellular carcinoma.