INS and type 1 diabetes mellitus: On the other hand, as the similar conjugate concept, it was reported that a hybrid insulin peptide composed of an insulin C-peptide fragment fused to a peptide from chromogranin A that was a T cell antigen in human type 1 diabetes, loaded on poly(lactide-co-glycolide) (PLG) nanoparticle, was developed and evaluated to exhibit the re-educative activity to T cells in an ex vivo study using the spleen and pancreas from euthanized mice [68].