BRAF and melanoma: A tumor containing BRAF-mutated melanoma cells exhibits low T cell infiltration and an upregulated level of proinflammatory cytokines, such as IL-6, IL-10, and vascular endothelial growth factor (VEGF), which leads to an increase in the number of immunosuppressive cells, such as Tregs or myeloid-derived suppressor cells, within the tumor microenvironment.