PTGS2 and cancer: Promotion of angiogenesis through the regulation of secretion of VEGF and IL-8 as well as adrenomedullin [95]Secretion of cancer-stimulating molecules, such as IL-1, TNFα, IFN-γ, angiotensin, COX-2, and IL-1β, to support the growth and metastasis of cancer cells as well as phenotype switch of TAMs toward the M2 type [96,97]Reduction in melanoma cells’ susceptibility to apoptosis induced by MEK inhibitors in a TNF-α- and MITF-dependent manner [99]